I would buy the exact same monitors again and do the following:
# Place the new 27" under the old one leaned back with something holding on the desk.
# Raise up the old 27" (if needed, use an Silverstones NUC extension bracket)
# Place the new 22" to the right.
On the other hand, I do have 6 monitors myself so I might be slightly insane....
Edit:
Oh, you only want two monitors?