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Even if they have different vram counts?

CPU: Intel Xeon E3 1231 V3 3.4ghz CPU COOLER: Cryorig H7 w/ Red Corsair SP120mm  MOBO: MSI SLI Krait Edition Z170 MEMORY: G.Skill Ripjaws 8gb (2x4) Storage: Kingston V300 120gb, WD 1TB GPU: MSI R9 390X CASE: Phantom 410 (ew) PSU: Thermaltake Toughpower Modular 550w CASE FANS: 4 CORSAIR SP120mm MONITOR: LG 25UM67 KEYBOARD: Das4 Ultimate Cherry MX Blue MOUSE: Deathadder Chroma Left-Handed AUDIO: Sennheiser HD598 Black, Astro A40s

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https://linustechtips.com/topic/511726-can-i-crossfire-a-380x-and-a-380-2gb/
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think so but it might be a bit finicky

Archangel (Desktop) CPU: i5 4590 GPU:Asus R9 280  3GB RAM:HyperX Beast 2x4GBPSU:SeaSonic S12G 750W Mobo:GA-H97m-HD3 Case:CM Silencio 650 Storage:1 TB WD Red
Celestial (Laptop 1) CPU:i7 4720HQ GPU:GTX 860M 4GB RAM:2x4GB SK Hynix DDR3Storage: 250GB 850 EVO Model:Lenovo Y50-70
Seraph (Laptop 2) CPU:i7 6700HQ GPU:GTX 970M 3GB RAM:2x8GB DDR4Storage: 256GB Samsung 951 + 1TB Toshiba HDD Model:Asus GL502VT

Windows 10 is now MSX! - http://linustechtips.com/main/topic/440190-can-we-start-calling-windows-10/page-6

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Yes you can, no it's not finecky and both cards will only run as 380s.

Main Rig:-

Ryzen 7 3800X | Asus ROG Strix X570-F Gaming | 16GB Team Group Dark Pro 3600Mhz | Corsair MP600 1TB PCIe Gen 4 | Sapphire 5700 XT Pulse | Corsair H115i Platinum | WD Black 1TB | WD Green 4TB | EVGA SuperNOVA G3 650W | Asus TUF GT501 | Samsung C27HG70 1440p 144hz HDR FreeSync 2 | Ubuntu 20.04.2 LTS |

 

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Intel NUC running Server 2019 + Synology DSM218+ with 2 x 4TB Toshiba NAS Ready HDDs (RAID0)

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