The system instability was indeed caused by the fabric on the CPU. No amount of SOC or VDDP voltage tinkering is able to completely absolve the issue. However, adjusting the FCLK ratio AND decreasing the RAM speed has fixed the audio crackling and stability problems. It seems that, at least on ASUS BIOS, you have to manually adjust the RAM speed and FCLK speed to a 3:1 ratio. I'm not sure what the default EXPO presets were doing, but they were running the FCLK at something that my CPU couldn't handle, thus, causing the audio crackling and instability. Adjusting the RAM speed alone will not proportionately change the FCLK clock, from my testing, so these values must be adjusted together manually.
I do want to add too, that I had to remount my cooler due to not adding enough thermal paste. Crackling can be caused by the CPU overheating as well.