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Any downsides to populating 8 Ram slots?

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I have a X299 motherboard with 4*8 GB DDR4 2400 RAM, i want to upgrade my memory, the cheapest would be to buy 4 more 8 GB chips. Any downsides to this? Does speed decrease or any other problems? (I think it will be difficult to get  exactly the same modules)

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It can be harder on the IMC if you're trying to run zonkers fast RAM, but usually anyone populating all 8 DIMMs is going for capacity for workloads that actually use it, so they aren't OCing anyways as that brings instability. 

 

If you mix RAM kits they may not run the same XMP profile, but you can manually key in the speed and main timings, up voltage slightly if needed for stability, and let the motherboard sort the sub-timings. 

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I'm running 8x8GB 3000 in mine.

 

Seeing as the existing ram is only 2400, it's a pretty safe bet adding more ram and running at same 2400 speed will be fine. You might even see some uplift in memory performance presuming the existing ram is single rank, as having two per channel can help a LOT with some workloads.

Main system: Asus X299 TUF mark 2, i9-7920X, Noctua D15, Corsair Vengeance LPX RGB 3000 8x8GB, MSI 3070 Gaming Trio X, Corsair HX1000i, GameMax Abyss, Samsung 960 Evo 500GB, Crucial MX500 1TB, Sandisk Ultra II 960GB, Samsung 980 Pro 2TB, Acer Predator XB241YU 24" 1440p 144Hz G-Sync + HP LP2475w 24" 1200p 60Hz wide gamut
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I’m sure the baller looks will outway the cons. 

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Thanks for all the feedback, I will probably just buy 4 more then, and try to get some with as similar timings as possible.

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