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Researchers create Nanotech chip that reprograms skin cells

WMGroomAK
By WMGroomAK
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I won't even to pretend to understand the biological aspects of this, but researchers at Ohio State University have developed a technology that can generate any cell type of interest within a patients body.  This new technology us being called Tissue Nanotransfection (TNT) and is a nanotech chip that when applied to the skin and has small electric current applied can reporgram skin cells into other types of cells.

Engadget Article: https://www.engadget.com/2017/08/08/Ohio-state-genetic-device-breakthrough-organ-tissue-repair/

OSU Article: https://news.osu.edu/news/2017/08/07/regenerative-med-study/

Quote

Researchers at The Ohio State University Wexner Medical Center and Ohio State’s College of Engineering have developed a new technology, Tissue Nanotransfection (TNT), that can generate any cell type of interest for treatment within the patient’s own body. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.

...

“By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining,” said Dr. Chandan Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State’s College of Engineering in collaboration with Ohio State’s Nanoscale Science and Engineering Center.

 

Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.

 

“This is difficult to imagine, but it is achievable, successfully working about 98 percent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you're off. The chip does not stay with you, and the reprogramming of the cell starts. Our technology keeps the cells in the body under immune surveillance, so immune suppression is not necessary,” said Sen, who also is executive director of Ohio State’s Comprehensive Wound Center.

 

TNT technology has two major components: First is a nanotechnology-based chip designed to deliver cargo to adult cells in the live body. Second is the design of specific biological cargo for cell conversion. This cargo, when delivered using the chip, converts an adult cell from one type to another, said first author Daniel Gallego-Perez, an assistant professor of biomedical engineering and general surgery who also was a postdoctoral researcher in both Sen’s and Lee’s laboratories.

 

TNT doesn’t require any laboratory-based procedures and may be implemented at the point of care. The procedure is also non-invasive. The cargo is delivered by zapping the device with a small electrical charge that’s barely felt by the patient.

 

“The concept is very simple,” Lee said. “As a matter of fact, we were even surprised how it worked so well. In my lab, we have ongoing research trying to understand the mechanism and do even better. So, this is the beginning, more to come.”

 

Researchers plan to start clinical trials next year to test this technology in humans, Sen said.

Really neat tech and if it works as described without any negative effects, then this will definitely be revolutionary for modern medicine.

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wait, so no more organ failure?

 

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4 minutes ago, Jito463 said:

So......they want to inject us with TNT?

 

e8ea4646c087927c6dec57c92c4a76c6--office

Not exactly sure on how all this works, but it appears to be a chip that is applied to the skin externally and has an electrical signal run through, almost like an Outpatient Procedure...

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16 minutes ago, Nikolithebear said:

I guess you can say this news is pretty.... explosive!!!!... Get it? TNT?... 

I'd lambast you for that horrible pun, but I effectively made the same joke, so I really have no leg to stand on. ;) 

https://linustechtips.com/main/topic/449522-smoking-barrels-ltts-unnofficial-gun-club/

 

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2 minutes ago, WMGroomAK said:

Not exactly sure on how all this works, but it appears to be a chip that is applied to the skin externally and has an electrical signal run through, almost like an Outpatient Procedure...

I'm sure this has some interesting potential for future medical procedures (probably in ways I can't even begin to imagine or understand), but you kind of opened Pandora's box with that TNT line. :D 

https://linustechtips.com/main/topic/449522-smoking-barrels-ltts-unnofficial-gun-club/

 

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Just now, Jito463 said:

I'm sure this has some interesting potential for future medical procedures (probably in ways I can't even begin to imagine or understand), but you kind of opened Pandora's box with that TNT line. :D 

I would say the researchers were feeling DYNAMITE about their work when coming up with a name.  Probably felt that there was a lot of explosive potential and were wanting to blow open a new world of medical technology. xD

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This seems pretty awesome but also probably potentially destructive, you can probably trigger cancer with that thing 

I spent $2500 on building my PC and all i do with it is play no games atm & watch anime at 1080p(finally) watch YT and write essays...  nothing, it just sits there collecting dust...

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The Toaster Project! Northern Bee!

 

The original LAN PC build log! (Old, dead and replaced by The Toaster Project & 5.0)

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#1. Treat others as you would like to be treated.

#2. It's best to keep your mouth shut; and appear to be stupid, rather than open it and remove all doubt.

#3. There is nothing "wrong" with being wrong. Learning from a mistake can be more valuable than not making one in the first place.

 

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2 minutes ago, JuNex03 said:

DID SOMEONE SAY NANOMACHINES!~?!?

maxresdefault.jpg

 

50 minutes ago, WMGroomAK said:

nanotech chip

Nope

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2 hours ago, WMGroomAK said:

Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.

Basically turning adult cells and turning them into induced pluripotent stem cells. This isn't something new and it can be achieved using growth factors and other substances. Stem cells especially embryonic stem cells can differentiate into all kinds of cells if given the right growth factors but research and use is pretty much limited due to ethical concerns. What's new with this is that it might give the cells more accuracy and reduce random mutations once an adult cell turns back into a pluripotent stem cell. 

 

I can see this being used in cancer treatment as well like in leukemia patients without a bone marrow match. Their skin cells can be used to become hematopoietic stem cells to replace the old marrow without rejection or create reprogrammed NK/cytotoxic T cells to specifically target cancer cells while leaving the normal cells unharmed. 

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I see the soul that is inside

 

 

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My childhood dream...  If you don't know then I'm sorry

 

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The problem is this stuff will never make it to consumers until the year 2080 when everyone is dead

▓ƆԀ▓ S▓₱▓Ɇ▓c▓s▓: i7 6ʇɥפᴉƎ00K (4.4ghz), Asus DeLuxe X99A II, GT҉X҉1҉0҉8҉0 Zotac Amp ExTrꍟꎭe),Si6F4Gb D???????r PlatinUm, EVGA G2 Sǝʌǝᘉ5ᙣᙍᖇᓎᙎᗅᖶt, Phanteks Enthoo Primo, 3TB WD Black, 500gb 850 Evo, H100iGeeTeeX, Windows 10, K70 R̸̢̡̭͍͕̱̭̟̩̀̀̃́̃͒̈́̈́͑̑́̆͘͜ͅG̶̦̬͊́B̸͈̝̖͗̈́, G502, HyperX Cloud 2s, Asus MX34. פN∩SW∀S 960 EVO

Just keeping this here as a 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Posted
37 minutes ago, BuckGup said:

The problem is this stuff will never make it to consumers until the year 2080 when everyone is dead

This is the time when I wish you could do two expessions. Agree and funny.

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Posted

deus ex anyone.

 

I don't understand this shit, but it sounds great.

Grammar and spelling is not indicative of intelligence/knowledge.  Not having the same opinion does not always mean lack of understanding.  

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Posted

I don't get how some electric stimulation can even change already differentiated cells. 

Folding stats

Vigilo Confido

 

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Posted

Nanomachines. Cyborg virus yo! 

| Ryzen 7 7800X3D | AM5 B650 Aorus Elite AX | G.Skill Trident Z5 Neo RGB DDR5 32GB 6000MHz C30 | Sapphire PULSE Radeon RX 7900 XTX | Samsung 990 PRO 1TB with heatsink | Arctic Liquid Freezer II 360 | Seasonic Focus GX-850 | Lian Li Lanccool III | Mousepad: Skypad 3.0 XL / Zowie GTF-X | Mouse: Zowie S1-C | Keyboard: Ducky One 3 TKL (Cherry MX-Speed-Silver) | Beyerdynamic MMX 300 (2nd Gen) | Acer XV272U | OS: Windows 11 |

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