Can I mix RAM sizes in different channels?

[Cackumbabo]

I currently have this kit of memory installed: https://www.newegg.com/g-skill-16gb-288-pin-ddr4-sdram/p/N82E16820232884?Description=G.SKLILL%20Aegis%20DDR4&cm_re=G.SKLILL_Aegis%20DDR4-_-20-232-884-_-Product

 

This is currently occupying DIMMA2 and DIMMB2.

 

I am looking to upgrade my capacity. Would it be possible to upgrade using this kit: https://www.newegg.com/g-skill-32gb-288-pin-ddr4-sdram/p/N82E16820232885?Description=G.SKLILL%20Aegis%20DDR4&cm_re=G.SKLILL_Aegis%20DDR4-_-20-232-885-_-Product

 

It is the exact same product with the same timings, but double in capacity. As the memory is dual channel, would a hypothetical configuration of 48gb RAM total consisting of one 2x8gb kit and one 2x16gb kit work at full speed?

[Cackumbabo]

Yes, my workload requires significantly more ram than I currently have. It is not for gaming.

 

Thanks!