Lordy

Ok, you need to outsource this problem. I mean you got focusrite in and your audio is marginally better. 
 
Most of the time, I have to turn my stereo to 80-90 to hear you in the house. I can hear other streamers at 50 or lower. The hiss makes me think I left the water running. Then the intro comes on and all of my windows vibrate, stuff falls sometimes. 
 
But about the other problems-
 
Ok so, question @Slick, @LinusTech, @nicklmg-
Linus always says "we haven't touched anything since last week!"
Are you turning ALL of the equipment off? A week is a long time. 
I assume you know to turn of or maybe hibernate the PC, but the other stuff? 
No experience with epiphan, but are  the capture cards off and NOT on usb ports that are powered when the PC is off?
Is ALL of the audio and video equipment on power strips that are turned off? 

A week is a long time. Shit just fucks up. A mixer does something weird, loses phantom power, a capture card screws up, an HDMI splitter overheats (Almost all do sometimes, believe me)
 
So something to think about
 
Another idea-
Duplicate your stream settings to your recording settings in OBS. 
Maybe start by being 25 minutes late instead of 30. 
Record 30 seconds. Talk loud like the show. Make it fun. Maybe run through George Carlin's seven dirty words real quick 
Shit!
Piss!
Fuck!
Cunt!
Cocksucker!
Motherfucker!
Tits!
Maybe run the intro as well. 
 
Listen to it. 
If it's good start broadcasting! 
 
Either way when it comes to troubleshooting it's clear there's a difference between recording videos and doing it live

Sorry for the late posting.
 
i ended up going for this
Gigabyte GA-H97N-WIFIIntel Pentium G3240 3.1GhzTeam Elite Dark 2x8GB DDR3 1600MHz (TDD38G1600HC901)Corsair Force LS 60GB SSD Sata 3Fractal Design Node 8048x 3TB WD Green`s  And was a tight fit to get all does 8 drives into the 804. probably should invest in some 90 degrees sata/power plugs 
 
But iam thinking of changing out the stock fans. with some Noctua fans.  
But since this motherboard only have 1 free  woundering how can i do this ?
 
What i want is kinda this,. That the fan rpm speed go based on cpu heat.  
So i assume i would need some kind of pwm splitter to connect to my singel free sys_fan port ? 
 
Did not linus review something like this in a video not to long ago ?  *just cant remember what and when*