Most likely, yes. It will definitely be functional, just might be slightly bottlenecked by the B450's PCI-E 2.0 support. I would suggest upgrading to a $120 B550 or X570 board to get the most performance. The X570 will also help future proof your system, and B550's don't have backwards compatibility, so you would need a new CPU if you decide you want a B550.
In that case you could go for a 3600 and 1TB SSD:
PCPartPicker Part List
Type
Item
Price
CPU
AMD Ryzen 5 3600 3.6 GHz 6-Core Processor
$173.99 @ Amazon
Motherboard
ASRock B450M PRO4 Micro ATX AM4 Motherboard
$82.99 @ Newegg
Memory
G.Skill Ripjaws V Series 16 GB (2 x 8 GB) DDR4-3200 CL16 Memory
$56.99 @ Newegg
Storage
Kingston A2000 1 TB M.2-2280 NVME Solid State Drive
$119.99 @ Amazon
Video Card
Asus GeForce GTX 1660 SUPER 6 GB TUF GAMING OC Video Card
$229.99 @ B&H
Case
Fractal Design Focus G ATX Mid Tower Case
$56.98 @ Newegg
Power Supply
be quiet! Pure Power 11 500 W 80+ Gold Certified ATX Power Supply
$69.90 @ B&H
Prices include shipping, taxes, rebates, and discounts
Total
$790.83
Generated by PCPartPicker 2020-08-07 19:18 EDT-0400
Or go for a 5600XT which should provide a decent bump in gaming performance:
PCPartPicker Part List
Type
Item
Price
CPU
AMD Ryzen 3 3100 3.6 GHz Quad-Core Processor
$129.99 @ B&H
Motherboard
ASRock B450M PRO4 Micro ATX AM4 Motherboard
$82.99 @ Newegg
Memory
G.Skill Ripjaws V Series 16 GB (2 x 8 GB) DDR4-3200 CL16 Memory
$56.99 @ Newegg
Storage
ADATA XPG SX8200 Pro 512 GB M.2-2280 NVME Solid State Drive
$69.98 @ Amazon
Video Card
Sapphire Radeon RX 5600 XT 6 GB PULSE Video Card
$299.99 @ Amazon
Case
Fractal Design Focus G ATX Mid Tower Case
$56.98 @ Newegg
Power Supply
be quiet! Pure Power 11 500 W 80+ Gold Certified ATX Power Supply
$69.90 @ B&H
Prices include shipping, taxes, rebates, and discounts
Total
$766.82
Generated by PCPartPicker 2020-08-07 19:19 EDT-0400
🤷♂️ maybe AMD's just low on fully functional CCXes and they need to keep them for the higher-end SKUs?