Intel(R) Core(TM) i5-7400 CPU
16 GB RAM
64bit Operating System
Nvidia GeForce GTX 1050 Graphics Card
So I've been having similar problems with a bunch of games which is extremely long loading screen times(and not loading at all sometimes), textures not loading/taking long to load in game, lagging audio even.
Games like Assassin's Creed Origins, DOOM, Sekiro... but also with games like TheCycle or Fortnite or Apex Legends. (All of which are installed on my external 1TB HDD)
I've also had a problem with CSGO which couldn't update(it would start updating then pause and start over) for some reason and I had to reinstall it for it to work.