Thank you @Jurrunio for your response ...some I understand for some I had to look-up to orient myself. You seem to know your stuff.
CPU:
Given, I already have a new 2920x (unless I can trade this in), I thought I'll get started w/ this one and eventually upgrade to 3960x, 3970x, 3990x or whatever the current one is/will be in future.
MOBO:
X399 | X570 | TXR40 ...with so many manufactures how do i pick the right one that can do the job for today and into the future?
If I went with a PCIe 4.0 MOBO (to future proof my build) will a PCI3 3.0 CPU work?
Who is your favourite manufacturer?
ASRock | ASUS | Gigabyte | MSI | did I miss anyone else?
I like the look of the new EATX form-factor, but realise it requires a bigger case, etc. etc.
I want to house both my GPUs and the workload needs multi-threading, hence the guidance to go with a Threadripper.
Purpose: This new build is to run a validator node and support a Web3 decentralised network as it starts hitting the mainstream audience.
Research: https://www.amd.com/en/products/specifications/processors/7746,7696,2571,2586,2601,2611,3376,9221,2481,11776,1736,1896,2466,176,146,116
Compare: 2920x 3960x, 3970x, 3990x https://www.amd.com/en/products/specifications/compare/processors/7941,8946,8941,9111