Hey,
I would go fr the Ryzen 3950x( beast of a processor). With an MSI unify or ace X570 to Overclock. And get a good cooler- NZXT kraken x72. Gen4 nvme ssd’s are super fast( see what’s available). For graphics if you want to save a little go for the 2080 super. Ram would be gskill trident a neo CL16 3600mhz.