Owner of a 450D here, I can tell you is an OK case but nothing more, it has some good airflow as long as you plan good for it. The space, well that's where I think it will fall very badly for you, it can be annoying, it can be done but in my opinion I think you could find better cases. Check Fractal Design, NZXT or Phanteks(these ones have good space for watercooling.).