I don't have those but I have the HS80's usually a restart fixes the issue but it did happen once that I had to reinstall the software to get it to work correctly. Yes like most peripheral software it kinda sucks. Sadly it's not the worse out there, Coolmaster software is worse.
If I leave that software running the keys on my keyboard just randomly stop working change what they do. My keyboard is not a Coolmaster is a Keychron