I have 2 9272-8i, that I only have 8 hdd but in theory you can put more, but I don't know how, because I'm going at 1GB / s and that's 3.0 x1, I just tried it with a rizer and it was going well, but since my lsi is 3.0 x8, I would like to use it whole or buy one that can use the entire x16, and for the gpu, I have no problem I have 64 lines in total.