That would throw off a lot of ITX systems of the CPU socket is on the back of the board.

I say put the CPU socket on the front, and put literally everything else on the back.

but then does it really matter which side is considered the "front" or "back"

Yes.

You'll have a heck of a time getting cooling to the back of a motherboard, especially in the ITX form factor.

I say we come up with a cubic motherboard standard instead of a square, to ascend into higher dimensions of computing for this multicore era.

inb4 Corsair builds a motherboard into their remake of the Obsidian 240D