ive done exactly what you're looking at and its works fine, thing is you have to look at fan size and its cfm and you make adjustments in bios or app, say if you're doing a 3 fan set up of a 150mm noctua exhaust and 2 80mm intake you'll most likely have neg presure but if you ramp up the intake and slow the exhaust down you'll probably get positive pressure so calculate it like that if you can and make adjustments where necessary.