64 GB of ram really is overkill for right now. I'd say you might need that ram in 7-10 years time, but by then I'm not sure your GPU and CPU would be able to match it. Memory is the easiest thing to upgrade, I'd say save the $270, and if you really need it in 5 years just drop it in. You also mentioned you liked the AIO because "It doesn't look super flashy," so you might be able to save by not getting RGB memory.
The 1080ti is also a very old part, it's pretty hard to find them any more. I can't find any on newegg for less than $1,200, which is about the same price as a 2080ti, which performs much better and has ray tracing, which you might want in the future. If that breaks your budget, a 2080 will also perform around the same as a 1080ti and costs only about $800, in actual stock.
Other than that it looks like a solid build. You had mentioned a monitor. I'm not an expert, but a good 144hz 1440p monitor with freesync or gsync should do you nicely. Just make sure you get a display port cable to run it off of, HDMI can't handle that much data.
Hope I could be of help.