Few things to disable when AMD driver misbehave.
1. Disable MPO. Yes this issue applies to Nvidia GPU as well but not as widespread.
https://nvidia.custhelp.com/app/answers/detail/a_id/5157/~/after-updating-to-nvidia-game-ready-driver-461.09-or-newer%2C-some-desktop-apps
2. Disable HAGS
3. Disable Hardware Acceleration (Internet browser, Steam, Discord, etc)
4. Disable automatic Windows Driver update. Sometime windows update will override AMD driver from AMD.com
Don't forget to reboot.
Also I noticed Radeon is more sensitive to system memory instability. Try clean and reseat your RAM or drop the timing/overclock.