You aren't going to need a Xeon, and it's really not worth buying the 8 core X99 chips if they're still 1K, because you're basically paying $700 for an i3's worth of performance.
And buy a 950 NVME SSD over that one.
You also probably do not really need the super high end GPUs, benchmarks are hard to find, but the performance per dollar really drops, unless you really need to hit that VRAM mark, also I don't think you get to use both card's VRAM even with workstation GPUs
Nvidia cards do CUDA, Firepro does OpenCL, I think adobe generally supports both, dunno about autoCAD, they probably support both, but the firepro cards generally seem to be better for the money
What you should probably do, is build 3 machines, the one below, maybe with a sabertooth board instead as it's a nice X99 board
Then you should spend some money on a NAS, for archiving and some form of back up
Then just build a network rendering rig, probably with even just an i7 6700 or OC'd 8300 if you don't care about power consumption, that way you can just throw video rendering onto that so your main rig is free to do other stuff
Essentially, don't put all your eggs into one basket man, unless you already have all of that
PCPartPicker part list: http://pcpartpicker.com/p/zhQ2Q7
Price breakdown by merchant: http://pcpartpicker.com/p/zhQ2Q7/by_merchant/
CPU: Intel Core i7-5820K 3.3GHz 6-Core Processor ($369.99 @ SuperBiiz)
CPU Cooler: Cooler Master Hyper 212 EVO 82.9 CFM Sleeve Bearing CPU Cooler ($29.49 @ Amazon)
Motherboard: ASRock X99 Extreme4/3.1 ATX LGA2011-3 Motherboard ($219.99 @ SuperBiiz)
Memory: Crucial 32GB (4 x 8GB) DDR4-2133 Memory ($107.99 @ Adorama)
Storage: Samsung 950 PRO 512GB M.2-2280 Solid State Drive ($317.00 @ Amazon)
Storage: Hitachi Deskstar NAS 4TB 3.5" 7200RPM Internal Hard Drive ($159.88 @ OutletPC)
Video Card: AMD FirePro W7100 8GB Video Card ($619.99 @ B&H)
Case: Fractal Design Define S ATX Mid Tower Case ($69.99 @ Newegg)
Power Supply: EVGA 750W 80+ Gold Certified Semi-Modular ATX Power Supply ($79.99 @ Amazon)
Total: $1974.31
Prices include shipping, taxes, and discounts when available
