I agree with pwn_intended. Keep MSI Afterburner open on your other screen. Detach the hardware monitor and see if your graphics card reaches its temp limit (the graph will either be at 0% at the bottom or at 100% at the top) while playing games.
Also keep a look at you CPU usage and hard disk/ssd usage. Neither of them should be even close to 100% during gaming (except for possibly the loading screens). If they are, you might have another problem.
Also, if I were you, I would back off a little with my overclock and test again. I really don't think its your overclock, but rather test it and be sure.
Or it might simply be a Driver problem? Uninstall the drivers to your Graphics card and install the newest ones?