I have a similar setup (LGA 1366). My dual X5675 CPUs @4.5ghz have no problem running even the most extreme hardware (980tis, Quadros, Firepros etc...). If you can get past 4ghz you won't see much of a bottleneck (esp. at 1440p or 4k) A newer, higher-IPC chip would be better for games, but in my use-case I need the most performance available in a <= 12 core package, which at the moment can only be had with a dual six-core OC setup.