Its officially a know issue
Known Issues
- Virtual Super Resolution settings may not retain after updating to this Radeon Software release.
- Wolfenstein II: The New Colossus™ may experience an application crash when disabling Asynchronous Compute via game settings.
- Graphics and memory clocks may remain at higher than expected values after watching a video or using Windows DVR while in game. A workaround is to reboot the system.
- Cursor or system lag may be observed on some system configurations when two or more displays are connected and one display is powered off.
- Radeon WattMan gauges may report as zero on secondary graphics products in multi GPU enabled system configurations.