Successfully passed through my resurrected GTX 1080 to a Windows VM. Now time to actually make said VM usable.
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Nah, that was my server we talked about, this is my desktop, but I ended up with XCP-ng for that and virtualized FreeNAS with a passed through HBA. Probably looking at setting up Looking Glass for my Windows VM.
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CPU pinning is easy. Just install lstopo and set Memory Interleave in your BIOS from Auto -> Channel.
The code for the .XML file can get a bit weird though.
I do expect that you'll run into the same problem I did on Debian where once you connect Looking Glass to the VM that you lose the ability to launch the VM. Don't know if the guide you're following covers the security changes you have to make.