Well, Many people would definitely say to go for wired. Because most of the time, it guarantees signal strength and reliability and I would agree with them on that.
For wireless, you have the convenience of plug and play with the only setup being drivers and entering the wifi password. Wifi also decreases clutter.
Personally, I run a 50Ft cable from my bedroom to the router in the living room. I run it along the ceiling by the molding so it nearly blends in with the surroundings for the most part.
You mentioned that you don't mind the trouble of managing the networking cable so what reason would you have to go with wireless? I may have a biased opinion but I believe that signal reliability and strength is the utmost importance of a good network. I ofc am a computer enthusiast and would do anything for the best. However, if you're a casual user and really all you do is surf the web and download movies and music, WiFi is just as good.
Have a look at Flexraid its a software raid it can do jbod and raid 1,5,6 (http://linustechtips.com/main/topic/33510-how-to-install-and-setup-flexraid-on-your-windows-storage-system/)
It what I'm going to use for my new NAS server. Really easy to add and replace drives